After that exit the control panel and you are done. Select disable option for your touchpad on ASUS laptop and press OK to save the new settings on your machine. Click on device setting and then on touchpad. You will see the mouse property box there. After selecting large icons, open the mouse. For this purpose, you just go to the start menu and click on the control panel. Method 2: From mouse settings: Another method to disable the touchpad on laptop is using your mouse settings.